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. 2020 Aug 3;5:143. doi: 10.1038/s41392-020-00252-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Regulation of the histone methylation of tumor-associated genes during digestive cancer development. Under certain conditions, aberrant methylation or demethylation of the corresponding cancer-related genes contributes to different processes and phenotypes during digestive cancer development, including carcinogenesis, proliferation, metabolic reprogramming, epithelial–mesenchymal transition, invasion, and migration. The blue circles indicate modifications that downregulate gene expression, while the red circles indicate modifications that upregulates gene expression