Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 3;10:12998. doi: 10.1038/s41598-020-69845-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The expression pattern of Unigenes and gene functional annotation. (A) The volcano plot exhibits the overall distribution of Unigenes, where red dots represent the up-regulated ones, blue the down-regulated ones, and gray the ones that are not significantly different. (B) Statistical histogram of differentially expressed Unigenes. (C) Functional annotation of the whole Unigenes shown as 42 categories of KEGG pathways. The right and left vertical axis respectively refer to the primary and secondary classification information of KEGG pathway. (D) KEGG enrichment scatterplot in which 29 pathways are annotated with differentially expressed Unigenes. Rich factor measures the number of differential genes located in the specific KEGG, and larger rich factor indicates higher degree of enrichment. (E) PCA based on KEGG annotation reveals intra-group similarity and inter-group difference and shows that ALS group differs from CON group in the functional profiles. Each point represents a functional profile of the participants, which of the same group are presented in the same color. PC1 and PC2 refer to the principal components and the percentages shows the extent of variation explained. Dataset reference: Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28, 27–30, 10.1093/nar/28.1.27 (2000).