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. 2020 Aug 3;10:13031. doi: 10.1038/s41598-020-69007-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of linear model: peak magnitudes (mean MFI for trial across individuals), half lives, and time-averaged mean response of IgG and IgG3 responses to gp41 and gp70_B.CaseA_V1V2. Estimated magnitude of response at peak (net MFI) to (A) gp41 and (B) V1V2 region. Estimated half life of antibody response (days) to (C) gp41 and (D) V1V2 region. Estimated time-averaged mean response to (E) gp41 and (F) V1V2 region across first 540 days after first vaccination. Error bars represent standard error. Refer to Table 1 for the trial specific strategies. Color represents the isotype of antibody (black IgG and red IgG3). Many trials lacked sufficient response to V1V2 (IgG and IgG3) and gp41 IgG for inclusion in model. 097-T1 data for gp41 IgG3 was excluded based on lack of decrease from peak to subsequent time point.