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. 2020 Aug 3;11:3869. doi: 10.1038/s41467-020-17681-9

Table 1.

Optimization of the reaction conditions.

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Entry metal salt Yield (%)a anti:synb ee (%)c
1 Sc(OTf)3/Ni(OTf)2/Mg(OTf)2 Trace — —
2 Y(OTf)3 60 2.2:1 96/−34
3 La(OTf)3 58 2.7:1 92/63
4 Yb(OTf)3 46 2.2:1 84/13
5d Y(OTf)3 73 5.2:1 97/0
6d,e Y(OTf)3 74 10:1 98/N.D.

Unless otherwise noted, all reactions were performed with metal salt/ligand (1:1, 2.5 mol%), E-1a (0.20 mmol) in CH2ClCH2Cl (1.0 mL) at 25 °C under N2 atmosphere for 24 h. aIsolated yield of anti-isomer. bDetermined by 1H NMR analysis of crude products. cDetermined by HPLC analysis on a chiral stationary phases. dToluene was used as solvent. eAddition of NEt3 (10 mol%) and for 12 h.