Figure 1.

Schematic diagram illustrating the roles of Vti1a in neurons. As in non-neuronal cells, Vti1a is part of a SNARE complexes that mediate endosome-trans-Golgi network (TGN) transport. Vti1a also mediates regulated secretion of dense core vesicles (DCV) and marks a pool of spontaneously fusing synaptic vesicles (green) that recycles at rest and fuse with the axonal presynaptic plasma membrane (PM). Vti1a and VAMP7 (VAMP7) are also involved in Potassium channel interacting protein 1 (KChIP1)/voltage-gated K+ channels (Kv4) to the somatodendritic plasma membrane. Mutations/variants and gene fusion of VTI1A (red star) in neuronal or glia progenitor cells could be oncogenic. See text for more details.