Table 1.

A summary of VTI1A and other SNARE family members with known genetic association with various cancers. VTI1A - Vesicle transport through interaction with T-SNAREs 1A (Vti1a); TCF7L2 - Transcription factor 7-like 2; CFAP46 - Cilia and flagella associated protein 46; VAMP2 – Vesicle-associated membrane protein 2; STX16 – Syntaxin 16; NRG1 – Neuregulin 1; NPEPL1 – Aminopeptidase-like 1.

Cancer and data type	Vti1a mutation/variant	Reference
Colorectal cancer (CRC) (primary tumor sample and matched adjacent tissues)	VTI1A-TCF7L2 gene fusion	Bass et al., 2011
CRC cell lines and tissues	Splice variants of VTI1A-TCF7L2 fusion transcripts	Nome et al., 2014
CRC genome wide association studies (GWAS)	Risk locus at 10q25 (rs12241008, intronic to VTI1A)	Wang et al., 2014
Non-small cell lung cancer association	Allele A of VTI1A SNP rs7086803	Su et al., 2015
Glioma GWAS	Risk locus at 10q25.2 (rs11196067), near the VTI1A gene locus	Kinnersley et al., 2015
CRC GWAS	Risk locus at 10q25.2 (rs10506868)	Zeng et al., 2016
Glioma association	Risk locus rs11196067	Wang et al., 2017a, Wang et al., 2017b
Associations between variants in the VTI1A-TCF7L2 region and cancer susceptibility	8 common variants of VTI1A and TCF7L2 associated with various cancers	Zhang et al., 2018
Hepatocellular carcinoma (HCC) RNA sequencing	VTI1A-CFAP46 fusion transcript (from a genomic DNA VTI1A-CFAP46 translocation event)	Tsuge et al., 2019
Non-small-cell lung adenocarcinoma, whole-transcriptome sequencing	VAMP2-NRG1 gene fusion	Jung et al., 2015
Gastrointestinal stromal tumors, exome and transciptome sequencing	STX16-NPEPL1 gene fusion	Kang et al., 2016