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. 2020 Jul 28;8:787. doi: 10.3389/fbioe.2020.00787

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Copyright © 2020 Wang, Zope, Islam, Rice, Dodman, Lipert, Chen, Zetter and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Physicochemical properties of Core-Shell PLNs. (a) The comparison of EE between with and without lipidation of R848 and SIL. (b) Representative TEM image of lipidated conjugates formulated with PLNs (Scale bar: left, 100 nm; right, 20 nm). (c) The mean hydrodynamic diameter (HD), (d) polydispersity index (PDI), and (e) zeta potential (ζ) of PLNs. (f) Optimum mean EE for mono-encapsulation of R848, SIL, C₁₆R848, C₁₆SIL, and co-encapsulation of C₁₆R848 and C₁₆SIL.