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. 2020 Jul 28;14:750. doi: 10.3389/fnins.2020.00750

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Copyright © 2020 Jia, Chen, Geng, Cheng, Li, Qiu, Huang, Wang, Zhang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glutamate chemical exchange saturation transfer imaging was feasible in human brain using the 3.0 T MR system. (A,B) In a healthy volunteer, GluCEST magnetic resonance image (MRI) could clearly distinguish white matter and gray matter, similar to T2_W imaging, and the gray matter signal intensity of GluCEST was higher than that of white matter. (C,D) In a patient with encephalitis, GluCEST imaging also clearly showed the left parietal cortex and subcortex lesion.