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. 2020 Jul 28;11:498. doi: 10.3389/fendo.2020.00498

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Copyright © 2020 Ikeda and Yamada.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ca²⁺ cycling thermogenesis in beige adipocytes the newly identified UCP1-independent thermogenic mechanism depends on ATP-dependent Ca²⁺ cycling via sacro-endoplasmic reticulumn ATPase 2b(SERCA2b) and the Ca²⁺ release channel ryanodine receptor 2 (RyR2).