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. 2020 Jul 28;8:536. doi: 10.3389/fcell.2020.00536

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Copyright © 2020 Hilderink, Devalla, Bosch, Wilders and Verkerk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Typical action potentials (APs) of atrial- and ventricular-like hiPSC-CM with and without I_K₁ injection. (A) Superimposed APs (top panel) of an atrial-like hiPSC-CM in absence (black line) and presence (red line) of 100% virtual I_K₁ injected through dynamic clamp and associated injected current (bottom panel) consisting of stimulus current and 0% or 100% virtual I_K₁. (B) Superimposed APs and associated injected current of a ventricular-like hiPSC-CM. APs elicited at 1 Hz by a 3-ms stimulus of 100 pA. Note difference in time scale between panels (A,B).