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. 2020 Jul 28;8:536. doi: 10.3389/fcell.2020.00536

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Copyright © 2020 Hilderink, Devalla, Bosch, Wilders and Verkerk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Control atrial- and ventricular-like hiPSC-CM APs. (A) AP parameters used for analysis: resting membrane potential (RMP), maximum upstroke velocity (dV/dt_max), AP amplitude (APA), AP duration at 20, 50, and 90% repolarization (APD₂₀, APD₅₀, and APD₉₀, respectively), and AP plateau amplitude at 50 ms after reaching dV/dt_max (APPlatA). (B) Superimposed typical APs of an atrial-like hiPSC-CM (red line) and a ventricular-like hiPSC-CM (blue line). (C) Superimposed APs (top panel) and associated net current consisting of stimulus current and virtual I_K₁ injected through dynamic clamp (bottom panel) of an atrial-like hiPSC-CM in absence (red line) and presence of 50 μM 4-aminopyridine (4-AP) (black line). (D) Superimposed APs (top panel) and associated net injected current (bottom panel) of a ventricular-like hiPSC-CM. APs elicited at 1 Hz by a 3-ms stimulus of 100 pA. Note difference in time scale between panels (C,D).