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. 2020 Jul 28;8:536. doi: 10.3389/fcell.2020.00536

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Copyright © 2020 Hilderink, Devalla, Bosch, Wilders and Verkerk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of injection of 100% virtual I_Kur through dynamic clamp on APs of atrial- and ventricular-like hiPSC-CMs. (A) Superimposed APs (top panel) of an atrial-like hiPSC-CM at 0% (red line) and 100% virtual I_Kur (black line) and associated net injected current (middle panel), consisting of I_K₁, 0% or 100% I_Kur, and a short stimulus current, as shown in the bottom panel in case of 100% I_Kur. (B) Superimposed APs (top panel), associated net injected current (middle panel), and its individual components in case of 100% I_Kur (bottom panel) of a ventricular-like hiPSC-CM. (C,D) Phase plane plots (top panel) of the action potentials and injected currents of panels (A,B) with their individual components in case of 100% I_Kur (bottom panel). APs elicited at 1 Hz by a 3-ms stimulus of 100 pA. Note difference in time scale between panels (A,B).