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. 2020 Jul 28;8:536. doi: 10.3389/fcell.2020.00536

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Copyright © 2020 Hilderink, Devalla, Bosch, Wilders and Verkerk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of I_Kur loss-of-function mutations on APs of atrial- and ventricular-like hiPSC-CMs. (A) Superimposed APs of an atrial-like hiPSC-CM upon injection of 12.5–100% virtual I_Kur through dynamic clamp and associated injected current (bottom panel), consisting of I_K₁, 12.5–100% I_Kur, and a short stimulus current. (B) Superimposed APs (top panel) and associated injected current (bottom panel) of a ventricular-like hiPSC-CM. APs elicited at 1 Hz by a 3-ms stimulus of 100 pA. Note difference in time scale between panels (A,B).