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. 2020 Jul 28;11:1558. doi: 10.3389/fimmu.2020.01558

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Copyright © 2020 Ge, Huang and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular sources and receptors of interleukin-17. Interleukin (IL)-17 family includes isoforms A to F. IL-17 can be induced by a variety of cells including T helper (Th) 17 cells, γδT cells, natural killer T (NKT) cells, group 3 innate lymphoid cells (ILC3s), CD8⁺ (Tc17) cells, neutrophils, microglia, mast cells, myeloid cells in the lung and kidneys, and Paneth cells in the intestine. In addition, antigen-presenting cells (APCs) stimulate the production of IL-17in response to stress proteins, pathogen-associated molecular patterns (PAMPs), or microbial metabolites. IL-17 receptor (IL-17R) family is composed of IL-17RA, IL-17RB, IL-17RC, IL-17RE, as well as IL-17RA and C heterodimeric complex.