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. 2020 Jul 28;11:1726. doi: 10.3389/fmicb.2020.01726

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Copyright © 2020 Muchaamba, Eshwar, von Ah, Stevens and Tasara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Strains vary in virulence and persistence within zebrafish: (A) In zebrafish embryos infected using the blood stream injection route, both N843_15 and N843_10 were unable to induce any clinical signs or mortality 72 h post infection. The reference strains used N2306 (CC4) and LL195 (CC1) had induced 100%, whilst EGDe (CC9) and N12-1273 (CC412) had induced 100% and 50% mortality of the zebrafish embryos within 24 and 72 h of infection, respectively. (B) GFP zebrafish embryo line coinfected with N843_15 mO2FP and N843_10 GFP. The parent strain N843_10 decreased in CFU numbers over time consistent with it being cleared while N843_15 levels remained unchanged over 48 h of infection. Results show the mean and standard deviation from 3 independent experiments. ^∗Indicates significant differences in the level of the two strains at 24 and 48 hpi (P < 0.05 based on repeated measures two-way ANOVA).