Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 4;10(3):561–579. doi: 10.1016/j.jcmgh.2020.04.014

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Development of inflammation, atrophy, and hyperplasia occurs earlier in Ebi3^-/- mice. (A) Representative H&E-stained sections of murine gastric corpus from 2-month-old BALB/c, TxA23, and Ebi3 knockout. Yellow box outlines high-magnification inset showing the degree of inflammation, parietal cell atrophy, mucinous hyperplasia/metaplasia, and mucosal hyperplasia. (B) Pathologic scores for inflammation, parietal cell atrophy, mucinous hyperplasia/metaplasia, and mucosal hyperplasia. Each dot represents the overall score given to 3 areas of gastric corpus from an individual 2-month-old mouse. N = 7–11 mice per group from more than 3 experiments. (C) Representative H&E-stained sections of murine gastric corpus from 12-month-old control TxA23 and TxA23xEbi3 knockout mice. Red arrows identify areas in Ebi3^-/- mice where glandular structures invade the submucosa and muscularis. A red box outlines abnormal branching glands and cellular atypia within the gastric corpus. N = 4 mice per group in at least 2 experiments.