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. 2020 May 4;10(3):561–579. doi: 10.1016/j.jcmgh.2020.04.014

Figure 6.

Figure 6

IL27 supplementation reverses atrophy and metaplasia in TxA23 mice with established chronic gastritis. (A) Representative images of H&E-stained sections of the gastric corpus from sham pump–treated and rIL27 pump–treated mice at 4 months of age 1 month after pump implantation. Yellow box indicates high-magnification inset image. (B) Pathologic scores for inflammation, parietal cell atrophy, mucinous hyperplasia/metaplasia, and mucosal hyperplasia. Each dot represents the overall score given to 3 areas of gastric corpus from an individual mouse. (C) Representative immunofluorescent staining indicating the extent of SPEM in the gastric corpus of sham control and rIL27-treated mice. Hoechst (blue), GSII (green), GIF (yellow), and CD44v9 (red). Yellow box indicates high-magnification inset image. N = 6–8 mice per group from 2 separate experiments. Statistical significance was determined using the Mann–Whitney U test.