Figure 2.

Capture of Molecules When Sites Are Distributed in Multiple Clusters

(A) Examples of the configuration of sites (250 in total) in 1, 2, 4, or 7 clusters. Bar: 60 nm.

(B) Number of bound molecules in synapses containing 250 sites, in steady state. Binding sites were distanced 10 nm (B1) or 15 nm (B2) and distributed in 1, 4, or 7 clusters. Simulated molecules were 1 or 10 nm in diameter (s1 and s10, respectively) and bound to the sites with P_bind = 0.9 (values of 20 independent simulations, overlaid with the mean ± SD, one-way ANOVA, ns: not significant; ∗∗∗∗p < 0.0001).