Figure 6.
Molecular Crowding Accelerate Synaptic Plasticity-like Change
Simulation of LTP-like (A and B) or LTD-like (C and D) changes in receptor trapping in synapses with 250 sites and 100 extra obstacles at t = 0, distributed in 1, 2, 4, or 7 clusters as indicated (colors in A1 and C1). Sites were distanced 10 (Dist 10) or 15 (Dist 15) nm. Pbind was changed at time = 15s (10 independent simulations in each case).
(A and C) Ratio of bound molecules (with respect to those bound at time = 15 s) versus time for LTP (A) or LTD (C) simulations. Mean (lines) ± SD (shaded areas).
(B and D) Ratio of bound molecules (with respect to those bound at time = 15 s) at 37.5s (early) or at 225s (late, shaded area) of simulation run for the simulations shown in A1 (B1), A2 (B2) and C1 (D1) and C2 (D2), respectively (median and 25%–75% IQR, whiskers: 5%–95% range, one-way ANOVA, ns: not significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001).