Fig. 1.

A general scheme of the canonical structures peculiar to each SVMP class. 1A depicts immature SVMPs and it encompasses a P–I class containing peptide signal sequence (PS), pro-domain (PD) and metalloproteinase (M) domain; P-II consist of PS, PD, M, spacer sequence (SS) and disintegrin (D) domain; and P-III contains PS, PD, M, SS, disintegrin-like (D) and cysteine rich (C) domains. 1B delineates processed SVMPs (without PS and PD). Thus, canonical structure of the matured P–I consists of only the M domain; P-II contains M, SS and D domains; and P-III is comprised of M, SS, D and C domains.