Table 1.

P–I SVMPs representatives and their reported activities.

	SVMP (P–I)	Molecular Mass (kDa)	Snake Species	Reported Activities	References
1.	HR2A	23.02	Trimeresurus flavoviridis	Hemorrhagic	Miyata et al., 1989, Takahashi and Ohsaka, 1970
2.	HT-2	25	Crotalus ruber	Hemorrhagic and fibrinogenolytic	Mori et al. (1987)
3.	HT-3	25.50	Crotalus ruber	Hemorrhagic and fibrinogenolytic	Mori et al. (1987)
4.	Atroxase	23.50	Crotalus atrox	Non-hemorrhagic and fibrinolytic	Willis and Tu (1988)
5.	Ht-d	23.23	Crotalus atrox	Hemorrhagic (degradation of fibronectin, laminin, type IV collagen, nidogen, and gelatins)	Shannon et al. (1989); Uniprot
6.	H2-proteinase	22.99	Trimeresurus flavoviridis	Non-hemorrrhagic and proteolytic	Takeya et al. (1989)
7.	LHF-II	22.3	Lachesis muta	Hemorrhagic, caseinolytic fibrinolytic and fibrinogenolytic	Sanchez et al. (2016)
8.	Jararafibrase III	21.4	Bothrops jararaca	Fibrinolytic and hemorrhagic	Maruyama et al. (1993)
9.	Jararafibrase IV	21.2	Bothrops jararaca	Fibrinolytic and hemorrhagic	Maruyama et al. (1993)
10.	Adamalysin II	24	Crotalus adamenteus	Endopeptidase, non-hemorrhagic, and inactivates serpins by limited proteolysis of their reactive-site loops	Gomis-Rüth et al. (1993); Uniprot
11.	BapI	24	Bothrops asper	Weakly hemorrhagic, fibrinogenolytic, caseinolytic and fibrinolytic	Gutiérrez et al. (1995)
12.	Acutolysin A	22	Agkistrodon acutus	Hemorrhagic	Gong et al. (1998)
13.	GramminelysinI	27.02	Trimeresurus gramineus	Fibrinogenolytic and apoptotic	Wu et al. (2001)
14.	EoVMP1	24	Echis ocellatus	Non-hemorrhagic and activates prothrombin (procoagulant)	Howes et al., 2003, Howes et al., 2005
15.	Agkislysin	22	Agkistrodon acutus	Fibrinogenolytic, fibrinolytic and prothrombin-activating	Wang et al. (2004)
16.	Insularinase	22.64	Bothrops insularis	Fibrinogenolytic, fibrinolytic and prothrombin-activating	de Albuquerque Modesto et al. (2005)
17.	FII	26 kDa	Agkistrodon acutus	Non-hemorrhagic	Lou et al. (2005)
18.	BjussuMP-II	24	Bothrops jararacussu	Antiplatelet, non-hemorrhagic, gelatinolytic, collagenolytic, fibrinolytic and fibrinogenolytic	Marcussi et al. (2007)
19.	BnP1	24	Bothrops neuwendi	Fibrinolytic and fibrinogenolytic	Baldo et al. (2008)
20.	Bothrojararactivase	22.83	Bothrops jararaca	Prothrombin-activating	Berger et al. (2008)
21.	Bj-PI	~ 25	Bothrops jararaca	Fibrinogenolytic and caseinolytic	Oliveira et al. (2009)
22.	Leucurolysin-A	23	Bothrops leucurus	Non-hemorrhagic and non-glycosylated-fibrinogenase	Ferreira et al. (2009)
23.	CcH1	25	Cerastes cerastes	Hemorrhagic	Boukhalfa-Abib et al. (2009)
24.	Batx-1	23.3	Bothrops atrox	Fibrinogenolytic and Hemorrhagic	Patiño et al. (2010)
25.	Bj-PI2	28.08	Bothrops jararaca	Non-hemorrhagic and fibrinolytic. It can recruit inflammatory cells	Da Silva et al. (2012)
26.	BpMP-I	20	Bothropoides pauloensis	Non-hemorrrhagic and fibrinogenolytic	Naves de Souza et al. (2012)
27.	BpirMP	23.1	Bothrops pirajai	Thrombocytic, fibrinogenolytic and fibrinolytic	Bernardes et al. (2013)
28.	BmooMPα-I	22.6	Bothrops moojeni	Kininogenase	Okamoto et al. (2014)
29.	Okinalysin	22	Ovophis okinavensis	Caseinolytic and hemorrhagic	Komori et al. (2014)
30.	BpMP-II	23	Bothropoides pauloensis	Azocaseinolytic. It can inhibit cell adhesion and angiogenesis	Achê et al. (2015)
31.	Bar-I	23.39	Bothrops barnetti	Non-hemorrhagic, fibrinogenolytic and fibrinolytic	Sanchez et al. (2016)