Table 3.

Sub-classification of P-III SVMPs and their activities.

	SVMP	Sub-class	Domains in processed forms	Snake Species	Activities	References
1.	Ohagin	P-IIIa	Metalloproteinase, disintegrin-like and cysteine rich domains	Ophiophagus hannah	Fibrinogenolytic activity and inhibition of ADP-induced platelet aggregation	Guo et al. (2007)
2.	VaF1	P-IIIa	Metalloproteinase, disintegrin-like and cysteine rich domains	Vipera ammodytes ammodytes	α-fibrinogenase activity	Leonardi et al. (2015)
3.	HR-Ele1	P-IIIa	Metalloproteinase, disintegrin-like and cysteine rich domains	Protobothrops elegans	Hemorrhagic, αβ-fibrinogenase, type I collagenase	Oyama and Takahashi (2015)
4.	Atrolysin A	P-IIIa	Metalloproteinase, disintegrin-like and cysteine rich domains	Crotalus atrox	Hemorrhagic, proteolytic, degrades plasma fibronectin, type-I collagenase, type-IV collagenase, fibrinogenase, gelatinase, sheddase of glycoprotein VI,	Fox and Bjarnason, 1995, Pinto et al., 2007
5.	Albocollagenase	P-IIIa	Metalloproteinase, disintegrin-like and cysteine rich domains	Cryptelytrops albolaris	Inhibition of collagen-induced platelet aggregation, type IV collagenase	Pinyachat et al. (2011)
6.	Alternagin-C	P-IIIb	Disintegrin-like domain linked to a cysteine-rich domain	Bothrops alternatus	Inhibition of integrin-collagen interaction, inhibition of angiogenesis in HUVECs	Cominetti et al., 2004, dos Santos et al., 2020, Selistre-de-Araujo et al., 2005, Souza et al., 2000
7.	Catrocollastatin	P-IIIb	Disintegrin-like domain linked to a cysteine-rich domain	Crotalus atrox	Inhibition of collagen-induced platelet aggregation	Fox and Serrano, 2008b, Zhou et al., 1995
8.	Baltergin-C	P-IIIb	Disintegrin-like domain linked to a cysteine-rich domain	Bothrops alternatus	Hemorrhagic, type IV collagenase	Gay et al. (2009)
9.	SV-PAD-2	P-IIIc	Dimeric; each monomer contains: a metalloproteinase, a disintegrin-like and a cysteine-rich domain	Protobothrops elegans	αβγ-fibrinogenase inhibition of ADP- and collagen-induced inhibition of platelet aggregation	Oyama and Takahashi (2015)
10.	AHPM	P-IIIc	Dimeric; each monomer contains: a metalloproteinase, a disintegrin-like and a cysteine-rich domain	Agkistrodon halys pallas	α-fibrinogenase, inhibition of ADP-induced platelet aggregation	Song et al. (2013)
11.	VaH3	P-IIIc	Dimeric; each monomer contains: a metalloproteinase, a disintegrin-like and a cysteine-rich domain	Vipera ammodytes ammodytes	Proteolytic cleavage of prothrombin, X factor as well as BM and ECM protein components	Sajevic et al. (2013)
12.	VaH4	P-IIIc	Dimeric; each monomer contains: a metalloproteinase, a disintegrin-like and a cysteine-rich domain	Vipera ammodytes ammodytes	Hemorrhagic (hydrolysis of ECM proteins) and cytotoxic activities against Hela cells	Leonardi et al. (2014)
13.	HV1	P-IIIc	Dimeric; each monomer contains: a metalloproteinase, a disintegrin-like and a cysteine-rich domain	Trimeresurus flavoviridis	Apoptosis of vascular endothelial cell in vitro	Masuda et al. (2001)
14.	VAP1	P-IIIc	Dimeric; each monomer contains: a metalloproteinase, a disintegrin-like and a cysteine-rich domain	Crotalus atrox	Fibrinogenolytic, Apoptosis of vascular endothelial cell in vitro	Masuda et al. (2000)
15.	VLFXAs	P-IIId	Metalloproteinase, disintegrin-like, cysteine-rich and two C-type lectin-like domains	Vipera ammodytes ammodytes	Activation of coagulation factor X to Xa, inhibition of collagen-induced platelet aggregation	Leonardi et al. (2008)
16.	RVV-X	P-IIId	Metalloproteinase, disintegrin-like, cysteine-rich and two C-type lectin-like domains	Daboia russelli	Inhibition of both ADP- and collagen-induced platelet aggregations	Takeya et al. (1992)
17.	Vaa-MPIII-3	P-IIIe	Disintegrin-like and cysteine-rich domains	Vipera ammodytes ammodytes	Hemorrhagic	Leonardi et al. (2019)