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. 2020 Jul 28;11:1146. doi: 10.3389/fphar.2020.01146

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Copyright © 2020 Wang, Ishfaq, Fan, Chen and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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7-Hydroxycoumarin (7-HC) alleviates kidney injury and the loss in renal function in colistin-induced kidney injury mice. (A) Hematoxylin and eosin (HE) staining of kidneys in the 7-HC group, no marked injury. (B) HE staining of kidneys in the control group, no marked injury. (C) HE staining of kidneys in the col group, extensive damage seen as renal tubule amplification, epithelial cells detachment, and necrosis. (D) HE staining of kidneys in the col + 7-HC group, mild tubular damage with necrosis of epithelial cells and cast formations. (E) Semiquantitative score (SQS) values that represent histopathological changes (n = 4). (F–H) Levels of serum neutrophil gelatinase-associated lipocalin (NGAL), Blood urea nitrogen (BUN) and creatinine (CRE), respectively (n = 6). Values are the mean ± SD that are significantly different indicated by asterisks as follows: ^**P < 0.01. Bars, 100 μm. Con, control; Col, colistin.