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. 2020 Jul 28;11:1146. doi: 10.3389/fphar.2020.01146

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Copyright © 2020 Wang, Ishfaq, Fan, Chen and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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7-Hydroxycoumarin (7-HC) significantly alleviates oxidative stress and apoptosis in colistin-induced kidney injury mice. (A–C) The levels of oxidative stress markers in the kidney tissues of mice in each group (n = 6). (D, E) Activities of caspase-3 and caspase-9 in the kidney tissues of mice in each group (n = 6). (F) Protein expression of Nrf2 and HO-1 in the kidney tissues of mice in each group (n = 3). Values are the mean ± SD that are significantly different indicated by asterisks as follows: ^**P < 0.01. Con, control; Col, colistin.