TABLE 1.
Clinical and genetic characteristics of 17 mcr-1-positive Enterobacteriaceae.
| Isolate |
Characterization |
||||||
| City | Specimen type | Date of isolation | Sequence type | mcr and beta-lactamase genes | O and H serotype | Inc type of mcr-1 carrying plasmid | |
| 14ZJ112 | Zhejiang | Gastric fluid | 2014.5 | ST46 | mcr-1, blaTEM–1B, blaTEM–209, blaCTX–M–55 | O114:H(NT)2 | IncX4 |
| 14ZJ121 | Zhejiang | Abdominal fluid | 2014.6 | ST48 | mcr-1, blaCTX–M–14 | O23:H11 | IncHI2A |
| 14ZJ121-T1 | NA | NA | NA | NA | mcr-1 | NA | IncHI2A |
| 14XY066 | Changsha | Gastric fluid | 2014.7 | ST410 | mcr-1, blaTEM–1B | O28:H45 | IncX4 |
| 14XY066-T | NA | NA | NA | NA | mcr-1 | NA | IncX4 |
| 14XY073 | Changsha | Abdominal fluid | 2014.7 | ST10 | mcr-1 | O68:H9 | IncX4 |
| 14XY073-T | NA | NA | NA | NA | mcr-1 | NA | IncX4 |
| 14TJ040 | Tianjin | Urine | 2014.5 | ST393 | mcr-1, blaTEM–1B, blaCTX–M–132 | O28:H1 | IncI2 |
| 14TJ040-T | NA | NA | NA | NA | mcr-1, blaCTX–M–132 | NA | IncI2 |
| 14XY087 | Changsha | Gastric fluid | 2014.8 | ST1011 | mcr-1, blaTEM–135 | O16:H34 | IncI2 |
| 14XY087-T | NA | NA | NA | NA | mcr-1 | NA | IncI2 |
| 14ZS127 | Zhongshan | Urine | 2014.4 | ST393 | mcr-1, blaTEM–1B, blaCTX–M–55 | O116:H1 | IncX4 |
| 14ZS127-T | NA | NA | NA | NA | mcr-1, blaCTX–M–55 | NA | IncX4 |
| 14GZ051 | Guangzhou | Pancreas | 2014.5 | ST2929 | mcr-1, blaCTX–M–14 | O28:H42 | IncHI2A |
| 14GZ051-T | NA | NA | NA | NA | mcr-1, blaCTX–M–14 | NA | IncHI2A |
| 14YF095 | Zhejiang | Gallbladder | 2014.5 | ST38 | mcr-1, blaTEM–1B, blaCTX–M–14 | O6:H18 | IncX4 |
| 14YF095-T | NA | NA | NA | NA | mcr-1, blaCTX–M–14 | NA | IncX4 |
| 14SD032 | shandong | Gallbladder | 2014.2 | ST2505 | mcr-1, blaTEM–1B, blaTEM–209, blaCTX–M–55 | O7:H21 | IncI2 |
| 15ZJ120 | Zhejiang | Abscess, abdominal | 2015.6 | ST10 | mcr-1, blaTEM–1B, blaOXA–1, blaCTX–M–27, blaCMY–2 | O28:H12 | p0111 |
| 15ZJ040 | Zhejiang | Urine | 2015.2 | ST10 | mcr-1, blaTEM–1B, blaOXA–1, blaCTX–M–65 | O28:H2 | IncX4 |
| 15SD112 | Shandong | Gallbladder | 2015.9 | ST971 | mcr-1, blaTEM–1B | O28:H25 | IncX4 |
| 16JL150 | Jilin | Abscess | 2016.2 | ST156 | mcr-1, blaTEM–1B | O(NT):H28 | IncHI2A |
| 16JL150-T | NA | NA | NA | NA | mcr-1 | NA | IncHI2A |
| 16GZ133 | Guangzhou | Abdominal fluid | 2016.3 | ST542 | mcr-1, blaTEM–1B, blaCTX–M–14 | O38:H40 | IncX4 |
| 16GZ091 | Guangzhou | Urine | 2016.5 | ST131 | mcr-1, blaTEM–1B, blaCTX–M–14 | O28:H(NT) | IncHI2A |
| 16GZ091-T | NA | NA | NA | NA | mcr-1, blaCTX–M–14 | NA | IncHI2A |
| 16GZ011 | Guangzhou | Urine | 2016.1 | ST648 | mcr-1, blaTEM–1B, blaCTX–M–55 | O39:H6 | IncI2 |
T: transconjugant; NT: non-typeable.