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. 2020 Jul 22;27:102359. doi: 10.1016/j.nicl.2020.102359

Table 3.

Summary of key findings for the most commonly implicated tracts by gene risk (APOE or FAD).

Tract Diagram Summary of APOE Findings Summary of FAD Findings
Corpus Callosum:
Connects the left and right cerebral hemispheres		 graphic file with name fx1.gif E4 carriers vs. non-carriers:
↓FA (Persson et al., 2006, Newlander et al., 2014, Heise et al, 2010, Cavedo et al., 2017, Zhang et al., 2015, Ryan et al., 2011, Slattery et al., 2017)‘↑MD (Heise et al, 2010, Cavedo et al., 2017, Cai et al., 2017, Zhang et al., 2015)
↑RD (Cavedo et al., 2017, Westlye et al., 2012)		 Pre-symptomatic carriers vs. controls:
↓FA (Sanchez-Valle et al, 2016)

Symptomatic carriers vs. controls:
↑MD (Sanchez-Valle et al., 2016, Parra et al., 2015)
↑LD (Sanchez-Valle et al, 2016)
↑RD (Sanchez-Valle et al, 2016)
Cingulum:
Connects the temporal and frontal lobes, cingulate and medial gyri of frontal, occipital, parietal and temporal lobes 		graphic file with name fx2.gif E4 carriers vs. controls:
↓FA (Lyall et al, 2014, Bagepally et al, 2012, Heise et al, 2010, Cavedo et al., 2017, Nierenberg et al., 2005)
↑MD (Li et al, 2012, Zhang et al., 2015, Cavedo et al., 2017, Adluru et al., 2014)
↑RD (Cavedo et al., 2017, Nierenberg et al., 2005)		 Pre-symptomatic carriers vs. controls:
↓MD (Ryan et al, 2013)
↑MD (Li et al, 2012)
↓LD (Ryan et al, 2013)

Symptomatic carriers vs. controls:
↓FA (Ryan et al, 2013)
↑MD (Ryan et al., 2013, Parra et al., 2015, Li et al, 2012)
↑LD (Ryan et al, 2013)
Inferior Occipito-Frontal Fascicle:
Connects the medial temporal lobe and the inferior frontal lobe 		graphic file with name fx3.gif E4 carriers vs. non-carriers:
↓FA (Persson et al., 2006, Cavedo et al., 2017)
↑MD (Operto et al, 2018)
↑LD (Operto et al, 2018)
↑RD (Cavedo et al., 2017, Westlye et al., 2012, Operto et al., 2018)		 No significant findings
Superior Longitudinal Fascicle:
Connects the frontal, parietal, occipital and temporal lobes		 graphic file with name fx4.gif E4 carriers vs non-carriers:
↓FA (Heise et al, 2010)
↑MD (Adluru et al., 2014, Operto et al., 2018, Cavedo et al., 2017, Heise et al, 2010)
↑RD (Operto et al., 2018, Westlye et al., 2012)
↑LD (Operto et al, 2018)		 Pre-symptomatic carriers vs non-carriers:
↑MD (Li et al, 2012)

Symptomatic carriers vs non-carriers:
↑MD (Li et al, 2012)
Inferior Longitudinal Fascicle:
Connects the occipital pole and temporal pole		 graphic file with name fx5.gif E4 carriers vs non-carriers:
↓FA (Lyall et al., 2014, Cavedo et al., 2017)
↑MD (Operto et al, 2018)
↑RD (Operto et al., 2018, Dowell et al., 2013, Cavedo et al., 2017)
↑LD (Operto et al, 2018)		 Pre-symptomatic carriers vs non-carriers:
↑MD (Parra et al, 2015, Li et al, 2012)

Symptomatic carriers vs non-carriers:
↑MD (Li et al, 2012)

Acronyms: E4 = APOE Epsilon 4; FAD = Familial Alzheimer’s Disease; FA = Fractional Anisotropy; MD = Mean Diffusivity; RD = Radial Diffusivity; LD = Longitudinal Diffusivity. Tract images were generated using FiberNavigator (Chamberland et al., 2014) and TractSeg (Wasserthal et al., 2018).