Table 3. Sex-specific, age- a nd multivariable-adjusted hazard ratios and 95% confidence intervals for mortality from cardiovascular disease according to quartiles of γ-GTP and one SD increment of log γ-GTP in total participants.
| Quartiles of γ-GTP |
HR1† | ||||
|---|---|---|---|---|---|
| Q1 (low) | Q2 | Q3 | Q4 (high) | ||
| Men | |||||
| Quartile range (IU/L) | 1–16 | 17–24 | 25–40 | 41–837 | |
| No. at risk | 4,123 | 4,074 | 3,841 | 3,949 | |
| Person-years | 35,697 | 34,752 | 32,487 | 33,606 | |
| Stroke | |||||
| No. of mortality | 39 | 40 | 31 | 36 | |
| Mortality rate | 1.09 | 1.15 | 0.95 | 1.07 | |
| Age adjusted HR | 1.00 | 1.25 (0.80–1.96) | 1.24 (0.76–2.00) | 1.69 (1.06–2.71) | 1.31 (1.11–1.54) |
| Multivariable HR§ | 1.00 | 1.23 (0.77–1.94) | 1.23 (0.74–2.06) | 1.76 (1.02–3.03) | 1.39 (1.14–1.68) |
| Coronary heart disease | |||||
| No. of mortality | 28 | 29 | 24 | 20 | |
| Mortality rate | 0.78 | 0.83 | 0.74 | 0.60 | |
| Age adjusted HR | 1.00 | 1.19 (0.70–2.02) | 1.15 (0.66–2.00) | 1.08 (0.60–1.96) | 1.01 (0.82–1.25) |
| Multivariable HR§ | 1.00 | 1.25 (0.72–2.15) | 1.15 (0.63–2.11) | 1.03 (0.52–2.06) | 0.98 (0.76–1.26) |
| Total cardiovascular diseases | |||||
| No. of mortality | 97 | 105 | 85 | 74 | |
| Mortality rate | 2.72 | 3.02 | 2.62 | 2.20 | |
| Age adjusted HR | 1.00 | 1.27 (0.96–1.67) | 1.27 (0.95–1.71) | 1.31 (0.96–1.79) | 1.14 (1.02–1.27) |
| Multivariable HR§ | 1.00 | 1.32 (0.99–1.76) | 1.33 (0.96–1.82) | 1.39 (0.97–1.99) | 1.17 (1.03–1.33) |
| Women | |||||
| Quartile range (IU/L) | 1–9 | 10–13 | 14–18 | 19–435 | |
| No. at risk | 5,466 | 7,785 | 5,447 | 6,355 | |
| Person-years | 49,579 | 68,477 | 47,223 | 55,107 | |
| Stroke | |||||
| No. of mortality | 30 | 45 | 35 | 58 | |
| Mortality rate | 0.61 | 0.66 | 0.74 | 1.05 | |
| Age adjusted HR | 1.00 | 0.95 (0.59–1.52) | 0.97 (0.58–1.60) | 1.45 (0.91–2.32) | 1.30 (1.13–1.50) |
| Multivariable HR§ | 1.00 | 1.02 (0.62–1.67) | 1.03 (0.60–1.76) | 1.44 (0.85–2.44) | 1.28 (1.09–1.50) |
| Coronary heart disease | |||||
| No. of mortality | 7 | 9 | 14 | 23 | |
| Mortality rate | 0.14 | 0.13 | 0.30 | 0.42 | |
| Age adjusted HR | 1.00 | 1.04 (0.38–2.83) | 2.28 (0.90–5.82) | 3.50 (1.44–8.49) | 1.72 (1.39–2.12) |
| Multivariable HR§ | 1.00 | 0.97 (0.35–2.75) | 2.11 (0.79–5.68) | 3.33 (1.24–8.93) | 1.82 (1.41–2.34) |
| Total cardiovascular diseases | |||||
| No. of mortality | 59 | 93 | 69 | 119 | |
| Mortality rate | 1.19 | 1.36 | 1.46 | 2.16 | |
| Age adjusted HR | 1.00 | 0.99 (0.71–1.39) | 0.97 (0.68–1.40) | 1.52 (1.09–2.12) | 1.29 (1.17–1.43) |
| Multivariable HR§ | 1.00 | 1.04 (0.73–1.47) | 1.01 (0.69–1.48) | 1.58 (1.08–2.29) | 1.32 (1.17–1.47) |
Mortality rate is expressed as /1000 person-years.
†
HR1: HR for 1 SD of log γ-GTP.
§
Multivariable HR: adjusted for age (continuous), drinking status (never, quit, and regular), smoking status (never, former, 1–20/day and ≥ 21/day), body mass index (sex-specific quartile), systolic blood pressure (sex-specific quartiles), serum triglycerides levels (sex-specific quartiles), serum total cholesterol levels (sex-specific quartiles), aspartate aminotransferase (sex-specific quartiles) and alanine aminotransferase (sex-specific quartiles).