Table 1. Demographic and clinical characteristics and plasma lipid and lipoprotein concentrations before treatment in all the four patients reported.

Patient, Sex	Age	BMI	Years of LDL apheresis	CVD	Lipid profile (in mg/dl)
N1, Male combined heterozygosity c.1448G > A, c.1646G > A	25	25	19	Mild carotid stenosis	TC: 1000 TG: 150 HDL: 32 LDL: 900 Lp(a): 19
N2, Male homozygous c.1285G > A	22	25	10	AVR, Carotid stenosis	TC: 1100 TG: 130 HDL: 33 LDL: 950 Lp(a): 5.5
N3, Female Mutation status not available	47	28	2	CABG + AVR, Carotid surgery	TC: 1000 TG: 110 HDL: 18–30 LDL: 900 Lp (a): 16
N4, Male Mutation status not available	56	27	12	CABG x2, PCIx2, AVR, Carotid Surgery	TC: 800 TG: 110 HDL: 50 LDL: 780 Lp (a): 36

To convert cholesterol values (TC, HDL, and LDL) from mg/dl to mmol/l, multiply by 0.0259, and, for TGs, multiply by 0.0113. TC indicates total cholesterol, TG indicates triglycerides, LDL indicates low-density lipoprotein, HDL indicates high-density lipoprotein. Lp (a) indicates lipoprotein (a), CABG indicates coronary artery bypass grafting; AVR indicates aortic valve replacement; PCI indicates percutaneous coronary intervention.