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. 2020 Jul 28;10:1291. doi: 10.3389/fonc.2020.01291

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Copyright © 2020 Xia, Zhong, Chen, Lai, Huang, Liu, Dong, He, Lin and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histochemical and immunohistochemical examinations of the tumor from our case. (A) LCNEC of the bladder showed large cells with large nuclear size, prominent nucleoli, and abundant cytoplasm. (H&E staining, ×400). The neoplasm displayed positive expression of CgA (B), strong and diffused expression of Syn (C), absent NSE expression (D), positive for CD56 (E), and the proliferative index Ki67 was 90% (F). A final diagnosis of LCNEC was performed. LCNEC, large cell neuroendocrine carcinoma; H&E, hematoxylin and eosin; CgA, Chromogranin A; Syn, synaptophysin; NSE, neuron specific enolase.