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. 2020 Jul 28;10:1291. doi: 10.3389/fonc.2020.01291

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Copyright © 2020 Xia, Zhong, Chen, Lai, Huang, Liu, Dong, He, Lin and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall Kaplan–Meier survival curves for patients with LCNEC. (A) Survival of all patients. (B) Survival of patients stratified according to TNM stage. (C) Survival of patients stratified according to T stage. (D) Survival of patients stratified according to M stage. (E) Multimodality therapy vs. single therapy according to pure LCNEC of the bladder. (F) Multimodality therapy vs. Single therapy according to pathologic stage T3–4. LCNEC, large cell neuroendocrine carcinoma; ACT, adjuvant chemotherapy.