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Preparation of flavanones (3, 4, and 5) via Claisen-Schmidt condensation in alkaline medium of acetophenone A and benzaldehydes B (i: KOH/MeOH/H2O) to produce chalcones C, cyclization of chalcones C under mild alkaline conditions (ii: NaOAc, EtOH-H2O, reflux), and acid hydrolysis (iii: HCl 1N, MeOH, reflux) to obtain flavanones F. Reaction yields are shown in brackets.
