Table 6.
Biological activity of isolated and synthesized flavanones as 5-hLOX and 15-sLOX inhibitors.
| Compound | % of inhibition(5-hLOX) | % of inhibition(15-sLOX) | IC50(5-hLOX) | Ki(5-hLOX) | Type of inhibition |
|---|---|---|---|---|---|
| 1 | 61 ± 1.341 | 7 ± 3.125 | 11.31 µM ± 3.022 | 4.71 µM ± 1.542 | non-competitive |
| 2 | 93 ± 0.791 | 26 ± 3.955 | 0.10 µM ± 0.081 | 0.05 µM ± 0.012 | competitive |
| 3 | 88 ± 0.678 | N.D | 0.22µM ± 0.023 | 0.07µM ± 0.013 | competitive |
| 4 | 11.67 ± 2.45 | N.D | N.D | N.D | N.D |
| 5 | 2.57 ± 2.26 | N.D | N.D | N.D | N.D |
| NDGA | 93 ± 5.870 | N.D | 0.33 µM ± 0.15 | N.D | competitive |
Flavanones at 10 µM; IC50, Half inhibitory concentration; Ki, inhibitory constant; N.D, not determined; NDGA, nordihydroguaiaretic acid.