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. 2020 Jul 28;11:1131. doi: 10.3389/fphar.2020.01131

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Copyright © 2020 Liu, Huang, Chen, Xu, Ye and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GC inhibits LXA₄ biosynthesis in experimental PE rats. Pregnant rats were treated according to Experimental protocol 1. (A) Effect of Dex on placental LXA₄ levels in pregnant rats; (B) Effect of Dex on placental LTB₄ levels in pregnant rats; (C) Effect of Dex on ALOX15, ALOX15B, and ALOX5 protein expression in placenta of pregnant rats. Protein expression was detected by western blotting. The histogram represents means ± SEM of the densitometric scans for protein bands (n=7 rats in each group), normalized by comparison with β-Actin and Lamin B and expressed as a percentage of Control. Results are expressed as means ± SEM (n=7 rats in each group). *p < 0.05, **p < 0.01, and ***p < 0.001 versus control group, two-tailed Student’s t-test.