Figure 3.

LXA₄ ameliorates PE-related symptoms and placental oxidative stress of GC-mediated rat PE. Pregnant rats were treated according to Experimental protocol 2. Systolic blood pressure (SBP), 24 h urinary protein excretion and fetal weight are presented in (A–C) respectively; (D) Effect of LXA₄ on Dex-mediated placental HIF1A expression. HIF1A was detected by western blotting. The histogram represents means ± SEM of the densitometric scans for protein bands (n=7 rats in each group), normalized by comparison with Lamin B and expressed as a percentage of Control; (E) Effect of LXA₄ on Dex-mediated placental lipid peroxidation. Levels of lipid peroxidation were determined by using a commercially available TBARS kit. The measurements of lipid peroxidation represent the degree of placental oxidative stress. Results are expressed as means ± SEM (n=7 rats in each group). ***p < 0.001 versus control group, ^†P < 0.05, ^††P < 0.01 and ^†††P < 0.001 versus Dex group, one-way ANOVA with S-N-K posttest.