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. 2020 Jul 28;11:1131. doi: 10.3389/fphar.2020.01131

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Copyright © 2020 Liu, Huang, Chen, Xu, Ye and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LXA₄ inhibits GC-mediated ALOX5 activation and LTB₄ production in experimental PE rats. Pregnant rats were treated according to Experimental protocol 2. (A) Effect of LXA₄ on Dex-mediated placental ALOX5 nuclear translocation. ALOX5 nuclear translocation was detected by western blotting. The histogram represents means ± SEM of the densitometric scans for protein bands (n=7 rats in each group), normalized by comparison with Lamin B and expressed as a percentage of Control; (B) Effect of LXA₄ on Dex-mediated placental LTB₄ increase. Results are expressed as means ± SEM (n=7 rats in each group). **p < 0.01 and ***p < 0.001 versus control group, ^†P < 0.05 and ^††P < 0.01 versus Dex group, one-way ANOVA with S-N-K posttest.