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Plot of TSA for the effect of HFNC, COT, and NIV for preventing reintubation. (A) TSA for HFNC vs. COT; (B) TSA for NIV vs. COT; and (C) TSA for NIV vs. HFNC. TSA, trial sequential analysis; NIV, noninvasive ventilation; COT, conventional oxygen therapy; HFNC, high-flow nasal cannula.
