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. 2020 Jul 24;12:6279–6289. doi: 10.2147/CMAR.S253327

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© 2020 Huang and Du.

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Anti-tumor effect of various treatment strategies in the A549/DDP tumor-bearing mice. (A) Kaplan-Meier survival curves of A549/DDP tumor-bearing mice after treated by PUE (60 mg/kg), DDP (10 mg/kg), and combination of PUE and DDP (60 mg/kg+10 mg/kg) (n=10). Qualitative images (B) and quantitative analysis (C) of tumor volumes after the treatment of various formulations (n=5). Qualitative (D) and quantitative (E) determination of VEGF expression in tumor tissues by immunohistochemical staining. (F and G) Evaluation of the expression levels of cell apoptosis-related proteins (Ki67 and PCNA) after various treatments. (H and I) Evaluation of the expression levels of the Wnt/β-catenin pathway-related proteins (β-catenin, c-Myc, Cyclin D1, MMP3, and MMP9) after various treatments. Qualitative (J) and quantitative (K) determination of the damage rate of kidney tissues of mice after respectively treated by puerarin, cisplatin, and puerarin + cisplatin. *p < 0.05, compared with controls. ^#p < 0.05 compared with the cells only treated by DDP.