(a) Schematic of the cross-flow channel geometry with velocity profiles at the inlets and outlets. A cell initially located in one of the inflow channels flows into the cross-slot region, where it experiences maximal deformation at the stagnation point (SP), as shown in the blue box. (b) Shape changes of the cell as it flows through the cross-flow channel, according to the numerical simulation. As the cell progresses through the channel, the major and minor axes of the cells (a and b) were recorded. To see this figure in color, go online.