FIG 5.

Immunodeficiency and probability of survival in allogeneic HCT patients presenting with lower RTID caused by human respiratory syncytial virus. Immunodeficiency scoring index (left) and immunodeficiency grading (right) were calculated as indicated in Table 2 for 85 allogeneic HCT recipients diagnosed with HRSV lower RTID and compared for mortality. High-risk individuals, as identified by a high immunodeficiency scoring index (left, score of 7 to 12; red line), had a higher risk for mortality than those having a moderate index (left, score of 3 to 6; green line) or low index (left, score of 0 to 2; blue line) (OR, 10.5; 95% CI, 1.9 to 56.6; P = 0.01). Similarly, individuals with very severe immunodeficiency (right, 2 to 7 criteria; red line) had a higher risk for mortality than those with moderate immunodeficiency (right, 1 criterion, green line) or moderate risk (right, 0 criteria; blue line) (OR, 11.1; 95% CI, 2.8 to 45.1; P < 0.001). Both grading approaches predicted time to mortality, as demonstrated by Kaplan-Meier survival curves. (Reproduced from reference 78 with permission of John Wiley and Sons.)