TABLE 1.

Case definitions of CARV-RTID^a

Case definition
Case classification
Case types Possible case: meeting the clinical criteria of RTID Probable case: meeting the clinical criteria of RTID and having an epidemiological link Presumptive case: meeting the clinical criteria of RTID and the laboratory criteria (laboratory confirmed) Proven case: histological evidence of CARV pathology
Clinical criteria
New onset of 1 of the following systemic symptoms/signs in the previous 5 days Fever Feverishness Myalgia Nausea
AND
At least 1 of the following 4 respiratory symptoms Cough Sore throat Shortness of breath Coryza
AND
Clinician’s judgment that the illness is due to an infectious agent
Epidemiological criteria
An epidemiological link to human-to-human transmission, such as CARV activity in the community Contact with visitor, another patient, or healthcare worker
Laboratory criteria
Detection of CARV in a clinical specimen, preferably from the site of clinical involvement, by at least 1 of the following Nucleic acid amplification testing (NAT) Virus isolation by cell culture (VIC) Direct virus antigen detection (DAD)
AND
Exclusion of a major role of other etiologies (another infectious agent or disease)

^aModified from reference 5.