Table 2.
Univariate and multivariate analysis of IL-34 and clinicopathological factors affecting survival of patients with GC
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| IL-34 (low/high) | 2.205 (1.072–4.537) | 0.032 | 1.457 (0.639–3.325) | 0.371 |
| Gender | ||||
| Female/male | 0.886 (0.443–1.775) | 0.733 | ||
| Age (≤ 60/> 60) | 1.058 (0.573–1.955) | 0.857 | ||
| Diameter (< 5/≥ 5, cm) | 0.363 (0.189–0.698) | 0.002 | 0.495 (0.217–1.129) | 0.095 |
| Lymph node metastasis | ||||
| No/yes | 0.267 (0.122–0.582) | 0.001 | 0.772 (0.274–2.173) | 0.624 |
| Tumour differentiation | ||||
| Low (reference) | 1 | 0.545 | ||
| High | 0.725 (0.218–2.411) | 0.600 | ||
| Moderate | 0.693 (0.349–1.375) | 0.294 | ||
| Invasion depth | ||||
| T4 | 1 | 0.142 | 1 | 0.955 |
| T1 | 0.000 (0.000–) | 0.977 | 0.900 (0.000–) | 1.000 |
| T2 | 0.261 (0.084–0.808) | 0.020 | 1.528 (0.326–7.165) | 0.591 |
| T3 | 0.750 (0.380–1.478) | 0.405 | 1.049 (0.463–2.378) | 0.909 |
| TNM | ||||
| IV (reference) | 1 | 0.000 | 1 | 0.001 |
| I | 0.000 (0.000–) | 0.966 | 0.000 (0.000–) | 0.969 |
| II | 0.085 (0.028–0.260) | 0.000 | 0.075 (0.021–0.270) | 0.000 |
| III | 0.195 (0.068–0.559) | 0.002 | 0.154 (0.047–0.503) | 0.002 |
Bold italic values indicate significance (p < 0.05)