Table 3.
Univariate and multivariate analysis of CD68+ TAMs and clinicopathological factors affecting survival of patients in T3 stage of GC
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| CD68 (low/high) | 3.080 (1.135–8.360) | 0.027 | 5.471 (1.825–16.397 | 0.002 |
| Gender | ||||
| Female/male | 0.638 (0.216–1.886) | 0.416 | ||
| Age (≤ 60/> 60) | 1.052 (0.479–2.310) | 0.900 | ||
| Diameter(< 5/≥ 5, cm) | 0.464 (0.196–1.100) | 0.081 | ||
| Lymph node metastasis | ||||
| No/yes | 0.407 (0.167–0.993) | 0.048 | 0.363 (0.123–1.075) | 0.067 |
| Tumour differentiation | ||||
| Low (reference) | 1 | 0.436 | ||
| High | 0.269 (0.035–2.059) | 0.206 | ||
| Moderate | 0.825 (0.348–1.955) | 0.663 | ||
| TNM | ||||
| IV (reference) | 1 | 0.019 | 1 | 0.007 |
| II | 0.140 (0.029–0.683) | 0.015 | 0.061 (0.011–0.351) | 0.002 |
| III | 0.337 (0.070–1.619) | 0.174 | 0.101 (0.016–0.634) | 0.014 |
Bold italic values indicate significance (p < 0.05)