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. 2020 Jul 9;20(3):2537–2556. doi: 10.3892/ol.2020.11835

Table I.

miR-33a expression and roles in different types of cancer.

A, Digestive system: Hepatocellular carcinoma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)
Liu et al, 2018 Down PNMA1 Up EMT, proliferation, migration (29)
Guo et al, 2016; Li et al, 2019 Down TWIST1 Up EMT, invasion, proliferation (30,31)
Fang et al, 2013 Down β-catenin Up Proliferation (32)
Han et al, 2016 Down PBX3 Up Proliferation, metastasis, invasion, low survival (33)
Wu et al, 2019 Down HMGA2 Up Proliferation, migration, invasion, drug resistance (34,35)
Han et al, 2019
Meng et al, 2017 Down HSPA8 Up Cisplatin resistance (36)
Hou et al, 2017 Down ABCA1 Up Doxorubicin resistance (37)
Chang et al, 2017 Up PPARα Down Proliferation, apoptosis (38)

B, Digestive system: Gastric cancer
First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Wang et al, 2015 Down CDK6 Up Proliferation, cell cycle (41)
CCND1
PIM1
Chen et al, 2019 Down SNAI2 Up EMT, invasion, migration (42)
Wu et al, 2018 Down ZEB1 Up EMT, migration (43)

C, Digestive system: Colorectal cancer
First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Wang et al, 2019 Down PIM3 Up Proliferation, cell cycle (50)
Shan et al, 2017 Down ST8SIA1 Up Proliferation, invasion, drug resistance (51)
Yan et al, 2019 Down MTHFD2 Up Proliferation, migration, cell cycle (52)
Ibrahim et al, 2011 Down PIM1 Up Tumor growth (53)

D, Digestive system: Pancreatic cancer
First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Liang et al, 2015 Down PIM3 Up Proliferation, gemcitabine sensitivity (56)
Liang et al, 2015 Down β-catenin Up EMT, proliferation, gemcitabine sensitivity (57)

E, Digestive system: Gallbladder cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Zhang et al, 2016 Down TWIST1 Up EMT, proliferation, migration, invasion (59)

F, Digestive system: Esophageal squamous carcinoma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Zhang et al, 2019 Down ZEB1 Up Proliferation, migration (62)
Wang et al, 2017 Down SOX9 Up Proliferation (63)

G, Respiratory system: Non-small cell lung cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Du et al, 2017 Down METTL3 Up Proliferation (65)
Kang et al, 2018 Down CAND1 Up Proliferation, migration Cell cycle (66)
Amaar and Reeves et al, 2019 Down ABCA1 Up EMT, proliferation, migration, chemoresistance (67)
Yang et al, 2015 Down TWIST1 Up Migration, EMT (68)
Kang et al, 2017 Down CDK6 Up Cell cycle, tumor development (69)
Wang et al, 2020 Down KPNA4 Up Tumorigenesis, tumor development (70)

H, Respiratory system: Untyped lung cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Li et al, 2018 Down mTOR Up Proliferation, celastrol resistance (71)
Kuo et al, 2013 Down CDK6 Up Bone metastasis (72)
Pan et al, 2020 Down TWIST1 Up Proliferation, metastasis (73)
Rice et al, 2013 Down HMGA2 Up Migration (74)
Zhu et al, 2015 Down β-catenin Up Proliferation, cell cycle (75)
Boldrini et al, 2017 Down PD-1 Up Prognosis (76)

I, Head and neck: Laryngeal carcinoma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Karatas et al, 2018 Down PIM1 Up Proliferation, apoptosis (79)

J, Head and neck: Tongue squamous carcinoma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Zuo et al, 2018 Down ZEB1 Up Proliferation, migration, cell cycle (81)

K, Skin: Melanoma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Zhou et al, 2015 Cao et al, 2017 Down HIF1A Up Proliferation, migration, invasion, apoptosis, radiosensitivity (83,85)
Tian et al, 2016 Down CDK16 Up Proliferation (86)
Lv et al, 2018 Down N/A N/A Proliferation, migration, invasion (87,88)
Fu et al, 2019

L, Urinary system: Renal cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Jiang et al, 2019 Down MDM4 Up Proliferation, survival (91)

M, Endocrine system: Thyroid cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Takeshita et al, 2013 Down MYC Up Proliferation (93)

N, Nervous system: Glioma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Chang et al, 2017 Up SIRT6 Down Apoptosis (95)
Wang et al, 2014 Up PDE8A, UVRAG Down Self-renewal (96)

O, Musculoskeletal system: Osteosarcoma

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Jiang et al, 2017 Down AXL Up Proliferation (99)
Huang et al, 2018 Down CYR61 Up EMT, invasion (100)
Zhang et al, 2015 Down N/A N/A Proliferation (101)
Zhou et al, 2014 Up TWIST1 Down Cisplatin resistance, apoptosis (102)

P, Reproductive system: Prostate cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Karatas et al, 2017 Down PIM1 Up Proliferation, invasion, migration (106)
Li et al, 2017 Down EN-2 Up Proliferation, migration, invasion (107)
Dai et al, 2019 Down TGFBRI Up EMT, invasion, migration, metastasis (108)

Q, Reproductive system: Breast cancer

First author, year miR-33a expression Target gene Target gene expression Function (Refs.)

Zhang et al, 2015 Down ADAM9 Up Proliferation, migration (112)
ROS1
Wolfe et al, 2016 Down ABCA1 Up Radiosensitivity (113)
Weihua et al, 2020 Down EZH2 Up Proliferation, migration (114)
Guan et al, 2019 Down eFI5A2 Up EMT, doxorubicin sensitivity (115)

miR, microRNA; EMT, epithelial-mesenchymal transition; ABCA1, ATP-binding cassette transporter A1; AXL, AXL receptor tyrosine kinase; CAND1, Cullin associated and neddylation dissociated 1; CCND1, cyclin D1; CDK, cyclin-dependent kinase; CYR61, cysteine-rich angiogenic inducer 61; EN-1, engrailed homeobox 2; EZH2, enhancer of zeste homolog 2; HIF1A, hypoxia inducible factor 1 subunit α; HMGA2, high mobility group AT-hook 2; HSPA8, heat shock protein family A (Hsp70) member 8; MDM4, mouse double minute 4; METTL3, methyltransferase-like 3; MTHFD2, methylenetetrahydrofolate dehydrogenase 2; PBX3, pre-B-cell leukemia transcription factor 3; PD-1, programmed cell death protein 1; PDE8A, phosphodiesterase 8A; PIM1/3, Pim-1/3 proto-oncogene; PNMA1, paraneoplastic antigen Ma1; PPARα, peroxisome proliferator activated receptor α; SIRT6, sirtuin 6; SNAI2, Snail family transcriptional repressor 2; SOX9, SRY-box 9; ST8SIA1, ST8α-N-acetyl-neuraminide-α-2,8-sialyltransferase 1; TFGBRI, transforming growth factor β receptor 1; TWIST1, Twist basic helix-loop-helix transcription factor 1; UVRAG, UV radiation resistance associated; ZEB1, zinc finger E-Box binding homeobox 1.