Table I.
A, Digestive system: Hepatocellular carcinoma | |||||
---|---|---|---|---|---|
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Liu et al, 2018 | Down | PNMA1 | Up | EMT, proliferation, migration | (29) |
Guo et al, 2016; Li et al, 2019 | Down | TWIST1 | Up | EMT, invasion, proliferation | (30,31) |
Fang et al, 2013 | Down | β-catenin | Up | Proliferation | (32) |
Han et al, 2016 | Down | PBX3 | Up | Proliferation, metastasis, invasion, low survival | (33) |
Wu et al, 2019 | Down | HMGA2 | Up | Proliferation, migration, invasion, drug resistance | (34,35) |
Han et al, 2019 | |||||
Meng et al, 2017 | Down | HSPA8 | Up | Cisplatin resistance | (36) |
Hou et al, 2017 | Down | ABCA1 | Up | Doxorubicin resistance | (37) |
Chang et al, 2017 | Up | PPARα | Down | Proliferation, apoptosis | (38) |
B, Digestive system: Gastric cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Wang et al, 2015 | Down | CDK6 | Up | Proliferation, cell cycle | (41) |
CCND1 | |||||
PIM1 | |||||
Chen et al, 2019 | Down | SNAI2 | Up | EMT, invasion, migration | (42) |
Wu et al, 2018 | Down | ZEB1 | Up | EMT, migration | (43) |
C, Digestive system: Colorectal cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Wang et al, 2019 | Down | PIM3 | Up | Proliferation, cell cycle | (50) |
Shan et al, 2017 | Down | ST8SIA1 | Up | Proliferation, invasion, drug resistance | (51) |
Yan et al, 2019 | Down | MTHFD2 | Up | Proliferation, migration, cell cycle | (52) |
Ibrahim et al, 2011 | Down | PIM1 | Up | Tumor growth | (53) |
D, Digestive system: Pancreatic cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Liang et al, 2015 | Down | PIM3 | Up | Proliferation, gemcitabine sensitivity | (56) |
Liang et al, 2015 | Down | β-catenin | Up | EMT, proliferation, gemcitabine sensitivity | (57) |
E, Digestive system: Gallbladder cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Zhang et al, 2016 | Down | TWIST1 | Up | EMT, proliferation, migration, invasion | (59) |
F, Digestive system: Esophageal squamous carcinoma | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Zhang et al, 2019 | Down | ZEB1 | Up | Proliferation, migration | (62) |
Wang et al, 2017 | Down | SOX9 | Up | Proliferation | (63) |
G, Respiratory system: Non-small cell lung cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Du et al, 2017 | Down | METTL3 | Up | Proliferation | (65) |
Kang et al, 2018 | Down | CAND1 | Up | Proliferation, migration Cell cycle | (66) |
Amaar and Reeves et al, 2019 | Down | ABCA1 | Up | EMT, proliferation, migration, chemoresistance | (67) |
Yang et al, 2015 | Down | TWIST1 | Up | Migration, EMT | (68) |
Kang et al, 2017 | Down | CDK6 | Up | Cell cycle, tumor development | (69) |
Wang et al, 2020 | Down | KPNA4 | Up | Tumorigenesis, tumor development | (70) |
H, Respiratory system: Untyped lung cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Li et al, 2018 | Down | mTOR | Up | Proliferation, celastrol resistance | (71) |
Kuo et al, 2013 | Down | CDK6 | Up | Bone metastasis | (72) |
Pan et al, 2020 | Down | TWIST1 | Up | Proliferation, metastasis | (73) |
Rice et al, 2013 | Down | HMGA2 | Up | Migration | (74) |
Zhu et al, 2015 | Down | β-catenin | Up | Proliferation, cell cycle | (75) |
Boldrini et al, 2017 | Down | PD-1 | Up | Prognosis | (76) |
I, Head and neck: Laryngeal carcinoma | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Karatas et al, 2018 | Down | PIM1 | Up | Proliferation, apoptosis | (79) |
J, Head and neck: Tongue squamous carcinoma | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Zuo et al, 2018 | Down | ZEB1 | Up | Proliferation, migration, cell cycle | (81) |
K, Skin: Melanoma | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Zhou et al, 2015 Cao et al, 2017 | Down | HIF1A | Up | Proliferation, migration, invasion, apoptosis, radiosensitivity | (83,85) |
Tian et al, 2016 | Down | CDK16 | Up | Proliferation | (86) |
Lv et al, 2018 | Down | N/A | N/A | Proliferation, migration, invasion | (87,88) |
Fu et al, 2019 | |||||
L, Urinary system: Renal cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Jiang et al, 2019 | Down | MDM4 | Up | Proliferation, survival | (91) |
M, Endocrine system: Thyroid cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Takeshita et al, 2013 | Down | MYC | Up | Proliferation | (93) |
N, Nervous system: Glioma | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Chang et al, 2017 | Up | SIRT6 | Down | Apoptosis | (95) |
Wang et al, 2014 | Up | PDE8A, UVRAG | Down | Self-renewal | (96) |
O, Musculoskeletal system: Osteosarcoma | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Jiang et al, 2017 | Down | AXL | Up | Proliferation | (99) |
Huang et al, 2018 | Down | CYR61 | Up | EMT, invasion | (100) |
Zhang et al, 2015 | Down | N/A | N/A | Proliferation | (101) |
Zhou et al, 2014 | Up | TWIST1 | Down | Cisplatin resistance, apoptosis | (102) |
P, Reproductive system: Prostate cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Karatas et al, 2017 | Down | PIM1 | Up | Proliferation, invasion, migration | (106) |
Li et al, 2017 | Down | EN-2 | Up | Proliferation, migration, invasion | (107) |
Dai et al, 2019 | Down | TGFBRI | Up | EMT, invasion, migration, metastasis | (108) |
Q, Reproductive system: Breast cancer | |||||
First author, year | miR-33a expression | Target gene | Target gene expression | Function | (Refs.) |
Zhang et al, 2015 | Down | ADAM9 | Up | Proliferation, migration | (112) |
ROS1 | |||||
Wolfe et al, 2016 | Down | ABCA1 | Up | Radiosensitivity | (113) |
Weihua et al, 2020 | Down | EZH2 | Up | Proliferation, migration | (114) |
Guan et al, 2019 | Down | eFI5A2 | Up | EMT, doxorubicin sensitivity | (115) |
miR, microRNA; EMT, epithelial-mesenchymal transition; ABCA1, ATP-binding cassette transporter A1; AXL, AXL receptor tyrosine kinase; CAND1, Cullin associated and neddylation dissociated 1; CCND1, cyclin D1; CDK, cyclin-dependent kinase; CYR61, cysteine-rich angiogenic inducer 61; EN-1, engrailed homeobox 2; EZH2, enhancer of zeste homolog 2; HIF1A, hypoxia inducible factor 1 subunit α; HMGA2, high mobility group AT-hook 2; HSPA8, heat shock protein family A (Hsp70) member 8; MDM4, mouse double minute 4; METTL3, methyltransferase-like 3; MTHFD2, methylenetetrahydrofolate dehydrogenase 2; PBX3, pre-B-cell leukemia transcription factor 3; PD-1, programmed cell death protein 1; PDE8A, phosphodiesterase 8A; PIM1/3, Pim-1/3 proto-oncogene; PNMA1, paraneoplastic antigen Ma1; PPARα, peroxisome proliferator activated receptor α; SIRT6, sirtuin 6; SNAI2, Snail family transcriptional repressor 2; SOX9, SRY-box 9; ST8SIA1, ST8α-N-acetyl-neuraminide-α-2,8-sialyltransferase 1; TFGBRI, transforming growth factor β receptor 1; TWIST1, Twist basic helix-loop-helix transcription factor 1; UVRAG, UV radiation resistance associated; ZEB1, zinc finger E-Box binding homeobox 1.