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. 2020 Jul 21;8(7):230. doi: 10.3390/biomedicines8070230

Table 2.

Summary of meta-analysis of the effect of aspirin on ARDS.

Authors Enrolled Types of Studies Enrolled Study Numbers Medications Outcome Variables Results Between-Study Heterogeneity Conclusions
Panka et al. [44] 1 RCT, 7 OS 8 Aspirin the risk of ARDS pooled OR was 0.59 Q = 2.44, I2 = 68% A beneficial role for Aspirin in ARDS prevention and treatment.
Yu et al. [111] 1 RCT, 5 OS 6 Aspirin

  1. the risk of ARDS/ALI

  2. mortality.

 pooled OR was 0.71 I2 = 0%, P = 0.419 Aspirin could provide protective effect on the rate of ARDS/ALI, but it could not reduce the mortality.
Jin et al. [112] 7 OS 7 Antiplatelet agents (aspirin 75 to 300 mg daily), (clopidogrel, 75 mg daily), and ticlo- pidine.

  1. the risk of ARDS/ALI

  2. mortality.

 pooled OR was 0.68 I2 = 34% Pre-hospital antiplatelet therapy was associated with a reduced rate of ARDS but had no effect on the mortality in the subjects at high risk
Mohanney et al. [113] 17 OS 17 Aspirin and other antiplatelet agents

  1. the risk of ARDS/ALI

  2. mortality.

 pooled OR was 0.67 I2 = 25% Antiplatelet therapy had an improved survival, decreased incidence of ARDS
Wang et al. [43] 2 RCT, 7 OS 9 Aspirin and other antiplatelet agents

  1. the risk of ARDS/ALI

  2. mortality.

 pool OR was 0.68 from OS; but no significant difference in RCT I2 = 0.0%, p = 0.329 for RCT
I2 = 68.4%, p = 0.004 for OS		 Whether antiplatelet therapy is associated with a decreased incidence of ARDS in patients at a high risk of developing the condition remains unclear.