Inhibitory effects of WELC on OVX-induced bone loss. Sham or OVX mice were administered vehicle, WELC-L (100 mg/kg), or WELC-H (300 mg/kg) for five weeks. (A) The distal femora were scanned, and bone morphometric parameters (BMD, BV/TV, Tb.N, Tb.Sp, and Tb.Th) were analyzed. (B) Serum levels of CTX-I and PINP were measured. * pā < ā0.05, ** pā< 0.01 versus OVX group. WELC, water extract of Lysimachia christinae; OVX, ovariectomized; BMD, bone mineral density; BV/TV, trabecular bone volume fraction; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; CTX-I, cross linked C-telopeptide of type I collagen; PINP, procollagen type I N-terminal propeptide.