Table 2.
Meta-analysis for the odds ratio of various immunohistochemical expressions between thymic carcinoma and thymoma.
| Marker | Number of Subsets |
Fixed Effect [95% CI] |
Heterogeneity Test [p-Value] |
Random Effect [95% CI] |
Egger’s Test [p-Value] |
|---|---|---|---|---|---|
| Androgen receptor | 3 | 0.362 [0.120, 1.091] | 0.063 | 0.740 [0.065, 8.450] | 0.480 |
| beta-5t | 2 | 0.002 [0.000, 0.030] | 0.564 | 0.002 [0.000, 0.030] | - |
| beta-catenin | 2 | 0.829 [0.254, 2.704] | 0.022 | 0.512 [0.027, 9.722] | - |
| Bcl-2 | 4 | 2.461 [1.043, 5.807] | 0.637 | 2.461 [1.043, 5.807] | 0.871 |
| Calretinin | 1 | 19.429 [2.218, 170.165] | 1.000 | 19.429 [2.218, 170.165] | - |
| CD15 | 2 | 4.139 [1.413, 12.127] | 0.022 | 2.263 [0.130, 39.382] | - |
| CD1a | 2 | 0.052 [0.012, 0.223] | 0.073 | 0.028 [0.001, 0.623] | - |
| CD205 | 2 | 0.221 [0.064, 0.759] | 0.019 | 0.137 [0.006, 3.046] | - |
| CD5 | 11 | 52.560 [26.424, 104.547] | 0.972 | 52.560 [26.424, 104.547] | 0.034 |
| CEA | 2 | 45.273 [5.567, 368.160] | 0.505 | 45.273 [5.567, 368.160] | - |
| CK19 | 2 | 0.061 [0.016, 0.224] | 0.364 | 0.061 [0.016, 0.224] | - |
| CK5/6 | 4 | 0.191 [0.080, 0.459] | 0.022 | 0.294 [0.054, 1.607] | 0.283 |
| c-Kit | 12 | 41.444 [23.767, 72.267] | 0.771 | 41.444 [23.767, 72.267] | 0.024 |
| Cyclin D1 | 2 | 0.407 [0.128, 1.298] | 0.006 | 1.140 [0.022, 58.476] | - |
| E-cadherin | 3 | 0.340 [0.170, 0.680] | 0.001 | 0.400 [0.064, 2.516] | 0.167 |
| EGFR | 6 | 0.311 [0.130, 0.741] | 0.014 | 0.314 [0.066, 1.493] | 0.964 |
| Estrogen receptor | 1 | 0.319 [0.012, 8.254] | 1.000 | 0.319 [0.012, 8.254] | - |
| Glut-1 | 4 | 11.607 [3.003, 44.862] | 0.100 | 15.187 [2.082, 110.780] | 0.019 |
| HBME | 2 | 2.776 [0.337, 22.853] | 0.088 | 2.763 [0.076, 100.781] | - |
| IGF-1R | 6 | 10.216 [5.611, 18.602] | 0.005 | 9.465 [2.869, 31.221] | 0.806 |
| Mesothelin | 3 | 39.842 [12.067, 131.542] | 0.876 | 39.842 [12.067, 131.542] | 0.386 |
| MOC31 | 2 | 18.019 [4.366, 75.113] | 0.874 | 18.019 [4.366, 75.113] | - |
| MUC1 | 3 | 44.866 [11.273, 178.576] | 0.786 | 44.866 [11.273, 178.576] | 0.249 |
| p21 | 2 | 10.270 [2.862, 36.849] | 0.716 | 10.270 [2.862, 36.849] | - |
| p53 | 7 | 2.554 [1.077, 6.055] | 0.029 | 3.199 [0.759, 13.481] | 0.487 |
| p63 | 3 | 0.239 [0.094, 0.610] | 0.013 | 0.264 [0.028, 2.482] | 0.924 |
| PAX8 | 3 | 0.371 [0.107, 1.288] | 0.065 | 0.539 [0.058, 4.989] | 0.505 |
| Progesterone receptor | 2 | 1.681 [0.170, 16.597] | 0.597 | 1.681 [0.170, 16.597] | - |
| Survivin | 2 | 1.251 [0.358, 4.378] | 0.103 | 0.733 [0.056, 9.558] | - |
| TdT | 2 | 0.015 [0.003, 0.085] | 0.206 | 0.014 [0.001, 0.126] | - |
| Thrombomodulin | 1 | 0.449 [0.023, 8.896] | 1.000 | 0.449 [0.023, 8.896] | - |
| WT-1 | 1 | 4.953 [0.193, 127.130] | 1.000 | 4.953 [0.193, 127.130] | - |
CI, confidence interval.