Table 3.
Meta-analysis for the odds ratio of various immunohistochemical expressions between thymic carcinoma and thymoma type B3.
| Marker | Type | Number of Subsets | Fixed Effect [95% CI] |
Heterogeneity Test [p-Value] |
Random Effect [95% CI] |
Egger’s Test [p-Value] |
|---|---|---|---|---|---|---|
| beta-5t | Thymic carcinoma | 2 | 0.031 [0.004, 0.188] | 0.877 | 0.031 [0.004, 0.188] | - |
| Thymoma type B3 | 2 | 0.948 [0.706, 0.993] | 0.511 | 0.948 [0.706, 0.993] | - | |
| beta-catenin | Thymic carcinoma | 1 | 0.750 [0.448, 0.917] | 1.000 | 0.750 [0.448, 0.917] | - |
| Thymoma type B3 | 1 | 0.118 [0.030, 0.368] | 1.000 | 0.118 [0.030, 0.368] | - | |
| CD1a | Thymic carcinoma | 2 | 0.127 [0.036, 0.360] | 0.155 | 0.096 [0.012, 0.489] | - |
| Thymoma type B3 | 2 | 0.847 [0.680, 0.935] | 0.682 | 0.847 [0.680, 0.935] | - | |
| CD205 | Thymic carcinoma | 2 | 0.650 [0.461, 0.801] | 0.371 | 0.650 [0.461, 0.801] | - |
| Thymoma type B3 | 2 | 0.958 [0.757, 0.994] | 0.679 | 0.958 [0.757, 0.994] | - | |
| CD5 | Thymic carcinoma | 5 | 0.722 [0.610, 0.812] | 0.678 | 0.722 [0.610, 0.812] | 0.318 |
| Thymoma type B3 | 5 | 0.100 [0.039, 0.233] | 0.358 | 0.096 [0.035, 0.236] | 0.110 | |
| CEA | Thymic carcinoma | 1 | 0.750 [0.522, 0.892] | 1.000 | 0.750 [0.522, 0.892] | - |
| Thymoma type B3 | 1 | 0.029 [0.002, 0.336] | 1.000 | 0.029 [0.002, 0.336] | - | |
| c-Kit | Thymic carcinoma | 11 | 0.688 [0.607, 0.759] | 0.142 | 0.692 [0.591, 0.778] | 0.532 |
| Thymoma type B3 | 11 | 0.099 [0.060, 0.160] | 0.944 | 0.099 [0.060, 0.160] | 0.005 | |
| Glut-1 | Thymic carcinoma | 4 | 0.952 [0.862, 0.985] | 0.827 | 0.952 [0.862, 0.985] | 0.017 |
| Thymoma type B3 | 4 | 0.495 [0.351, 0.640] | 0.105 | 0.526 [0.296, 0.745] | 0.621 | |
| IGF-1R | Thymic carcinoma | 5 | 0.820 [0.720, 0.890] | 0.580 | 0.820 [0.720, 0.890] | 0.147 |
| Thymoma type B3 | 5 | 0.632 [0.495, 0.751] | 0.179 | 0.646 [0.468, 0.791] | 0.573 | |
| Mesothelin | Thymic carcinoma | 1 | 0.417 [0.185, 0.692] | 1.000 | 0.417 [0.185, 0.692] | - |
| Thymoma type B3 | 1 | 0.028 [0.002, 0.322] | 1.000 | 0.028 [0.002, 0.322] | - | |
| MOC31 | Thymic carcinoma | 1 | 0.500 [0.244, 0.756] | 1.000 | 0.500 [0.244, 0.756] | - |
| Thymoma type B3 | 1 | 0.118 [0.030, 0.368] | 1.000 | 0.118 [0.030, 0.368] | - | |
| MUC1 | Thymic carcinoma | 3 | 0.849 [0.706, 0.930] | 0.140 | 0.897 [0.666, 0.975] | 0.034 |
| Thymoma type B3 | 3 | 0.270 [0.144, 0.449] | 0.051 | 0.198 [0.048, 0.549] | 0.462 | |
| p21 | Thymic carcinoma | 1 | 0.667 [0.376, 0.869] | 1.000 | 0.667 [0.376, 0.869] | - |
| Thymoma type B3 | 1 | 0.118 [0.030, 0.368] | 1.000 | 0.118 [0.030, 0.368] | - | |
| TdT | Thymic carcinoma | 2 | 0.070 [0.018, 0.242] | 0.611 | 0.070 [0.018, 0.242] | - |
| Thymoma type B3 | 2 | 0.865 [0.690, 0.949] | 0.336 | 0.865 [0.690, 0.949] | - |
CI, confidence interval.