Table 4.
Diagnostic test accuracy review of various immunohistochemical markers for differentiation between thymic carcinoma and thymoma type B3.
| Marker | Included Studies | Sensitivity (%) [95% CI] |
Specificity (%) [95% CI] |
Diagnostic OR [95% CI] |
AUC on SROC |
|
|---|---|---|---|---|---|---|
| Thymic carcinoma | CD5 | 5 | 0.731 [0.622, 0.817] | 0.967 [0.756, 0.996] | 23.936 [7.693, 74.478] | 0.725 |
| c-kit | 11 | 0.709 [0.613, 0.790] | 0.925 [0.873, 0.957] | 23.623 [11.900, 46.894] | 0.910 | |
| Glut-1 | 4 | 0.942 [0.856, 0.978] | 0.464 [0.225, 0.720] | 11.823 [2.879, 48.549] | 0.916 | |
| IGF-1R | 3 | 0.875 [0.760, 0.939] | 0.250 [0.136, 0.415] | 4.050 [1.087, 15.085] | 0.758 | |
| MUC1 | 3 | 0.932 [0.686, 0.988] | 0.847 [0.505, 0.968] | 46.251 [11.634, 183.877] | 0.921 | |
| Thymoma type B3 | beta-5t | 2 | 1.000 [0.927, 1.000] | 1.000 [0.942, 1.000] | 571.396 [33.356, 9788.053] | 0.985 |
| CD1a | 2 | 0.743 [0.628, 0.832] | 0.952 [0.504, 0.997] | 35.919 [1.606, 803.371] | 0.871 | |
| CD205 | 2 | 1.000 [0.931, 1.000] | 0.335 [0.165, 0.504] | 11.735 [1.368, 100.632] | 0.785 | |
| TdT | 2 | 0.879 [0.718, 0.954] | 0.933 [0.769, 0.983] | 93.458 [14.682, 594.912] | 0.958 |
CI, confidence interval; OR, odds ratio; AUC, area under the curve; SROC, summary receiver operating characteristic.