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Cloning of FAT10 promoter region. (A) Comparison of the histocompatibility MHCI locus between human and mouse. (B) Scheme of mouse UbD Promoter. The size of the cloned UbD promoter is 4.2 Kb. p53 down-regulating UbD expression while TAT HIV sequence has been found to be involved in the up-regulation of UbD. One ISRE consensus sequence was found in the promoter at 3.5 Kb upstream from the starting point. (C) Comparison of the UbD ISRE, ISG15 ISRE and the consensus ISRE is shown [9].
