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Schematic diagram of Tec kinase signaling and FAT10 pathway. Schematic diagram of Tec kinase signaling activation by oxidative stress and multiple membrane receptors that are involved in a variety of downstream responses, including Ca2+ influx, proliferation, differentiation, and transformation. In alcoholic hepatitis, FAT 10 is the key molecule connected with TEC kinase pathway through STAT3 and NFκB modulations.
